Although all menopausal women experience the same physiological changes as they transition from pre-to postmenopausal, their physiological response – and therefore their requirements for hormone therapy – varies. Further, standardized dosing may fit the needs of groups of women, but not necessarily an individual woman.
The causes for a particular woman’s response to hormone therapy are varied. They may be related to differences in the absorption of estrogen and progesterone, existing risk factors, smoking history, or a number of other factors. The message is clear: Every woman responds uniquely to a given dose and route of BHRT. There is a difference, for example, between healthy women who are experiencing a natural, reproductive transition and patients who have latent or overt disease. An individualized, evidence-based approach allows us to evaluate the need for BHRT, the dose that should be prescribed, and the patient’s response to treatment over time.